Product Name :
MSDC 0160
Description:
MSDC 0160 (Mitoglitazone) is a mitochondrial target of thiazolidinediones (mTOT)-modulating insulin sensitizer and a modulator of mitochondrial pyruvate carrier (MPC). MSDC 0160 is a thiazolidinedione (TZD) with antidiabetic and neuroprotective activities. MSDC 0160 has the potential for Alzheimer′s disease.
CAS:
146062-49-9
Molecular Weight:
370.42
Formula:
C19H18N2O4S
Chemical Name:
5-(4-[2-(5-ethylpyridin-2-yl)-2-oxoethoxy]phenylmethyl)-1,3-thiazolidine-2,4-dione
Smiles :
CCC1=CN=C(C=C1)C(=O)COC1C=CC(CC2SC(=O)NC2=O)=CC=1
InChiKey:
IRNJSRAGRIZIHD-UHFFFAOYSA-N
InChi :
InChI=1S/C19H18N2O4S/c1-2-12-5-8-15(20-10-12)16(22)11-25-14-6-3-13(4-7-14)9-17-18(23)21-19(24)26-17/h3-8,10,17H,2,9,11H2,1H3,(H,21,23,24)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
MSDC 0160 (Mitoglitazone) is a mitochondrial target of thiazolidinediones (mTOT)-modulating insulin sensitizer and a modulator of mitochondrial pyruvate carrier (MPC). MSDC 0160 is a thiazolidinedione (TZD) with antidiabetic and neuroprotective activities. MSDC 0160 has the potential for Alzheimer′s disease.|Product information|CAS Number: 146062-49-9|Molecular Weight: 370.42|Formula: C19H18N2O4S|Synonym:|Mitoglitazone|CAY10415|Chemical Name: 5-(4-[2-(5-ethylpyridin-2-yl)-2-oxoethoxy]phenylmethyl)-1,3-thiazolidine-2,4-dione|Smiles: CCC1=CN=C(C=C1)C(=O)COC1C=CC(CC2SC(=O)NC2=O)=CC=1|InChiKey: IRNJSRAGRIZIHD-UHFFFAOYSA-N|InChi: InChI=1S/C19H18N2O4S/c1-2-12-5-8-15(20-10-12)16(22)11-25-14-6-3-13(4-7-14)9-17-18(23)21-19(24)26-17/h3-8,10,17H,2,9,11H2,1H3,(H,21,23,24)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 30 mg/mL (80.99 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.Garadacimab Purity & Documentation |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|MSDC 0160 (Mitoglitazone; 1-50 µM; for 24 hours) significantly decreases phosphorylation of mTOR at 20 and 50 µM.Paricalcitol manufacturer MSDC 0160 acts as insulin sensitizers without activating PPARγ.PMID:33349093 MSDC 0160 (10 μM; pretreatment 1 hour) prevents the MPP+ (10 μM)-induced loss of both tyrosine hydroxylase (TH)-immunoreactive differentiated Lund human mesencephalic (LUHMES) cells. MSDC 0160 (10 or 100 μM) prevents the loss of GFP-fluorescent dopaminergic neurons induced by MPP+ (0.75 mM) in nematodes. MSDC 0160 (10-20 μM) in conbination with IGF-1 prevents the loss of insulin content and maintains insulin secretion. MSDC 0160 (1-50 μM) treatment maintains human β-cell phenotype.|In Vivo:|MSDC 0160 (Mitoglitazone; 30 mg/kg; oral gavage; daily; for 7 days) improves locomotor behavior, increases survival of nigral dopaminergic neurons, boosts striatal dopamine levels, and reduces neuroinflammation in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice.|References:|Rohatgi N, et al. Novel insulin sensitizer modulates nutrient sensing pathways and maintains β-cell phenotype in human islets. PLoS One. 2013 May 1;8(5):e62012.Ghosh A, et al. Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration inexperimental models of Parkinson’s disease. Sci Transl Med. 2016 Dec 7;8(368):368ra174.Products are for research use only. Not for human use.|