The use of chemical inhibitors of TOR, this sort of as rapamycin, or mutations in TOR/Sch9 pathway proteins causes diminished pathway activity that encourages an extension of yeast longevity [7,eight]
Our final results also uncovered that reduction of DJ-1 function augmented the impairment of Nrf2 method activation and that the double transgenic SOD1 DJ-one KO mice showed decreased spinal Nrf2…