Product Name :
Talampanel
Description:
Talampanel (LY300164) is an orally and selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor antagonis with anti-seizure activity. Talampanel (IVAX) has neuroprotective effects in rodent stroke models. Talampanel attenuates caspase-3 dependent apoptosis in mouse brain.
CAS:
161832-65-1
Molecular Weight:
337.37
Formula:
C19H19N3O3
Chemical Name:
1-[(13R)-10-(4-aminophenyl)-13-methyl-4, 6-dioxa-11, 12-diazatricyclo[7.5.0.0, ]tetradeca-1(9), 2, 7, 10-tetraen-12-yl]ethan-1-one
Smiles :
CC(=O)N1N=C(C2=CC3OCOC=3C=C2C[C@H]1C)C1C=CC(N)=CC=1
InChiKey:
JACAAXNEHGBPOQ-LLVKDONJSA-N
InChi :
InChI=1S/C19H19N3O3/c1-11-7-14-8-17-18(25-10-24-17)9-16(14)19(21-22(11)12(2)23)13-3-5-15(20)6-4-13/h3-6,8-9,11H,7,10,20H2,1-2H3/t11-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Imatinib In stock
Shelf Life:
≥360 days if stored properly.FX-11 MedChemExpress
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32424550
Additional information:
Talampanel (LY300164) is an orally and selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor antagonis with anti-seizure activity. Talampanel (IVAX) has neuroprotective effects in rodent stroke models. Talampanel attenuates caspase-3 dependent apoptosis in mouse brain.|Product information|CAS Number: 161832-65-1|Molecular Weight: 337.37|Formula: C19H19N3O3|Synonym:|GYKI-53773|LY-300164|Chemical Name: 1-[(13R)-10-(4-aminophenyl)-13-methyl-4, 6-dioxa-11, 12-diazatricyclo[7.5.0.0, ]tetradeca-1(9), 2, 7, 10-tetraen-12-yl]ethan-1-one|Smiles: CC(=O)N1N=C(C2=CC3OCOC=3C=C2C[C@H]1C)C1C=CC(N)=CC=1|InChiKey: JACAAXNEHGBPOQ-LLVKDONJSA-N|InChi: InChI=1S/C19H19N3O3/c1-11-7-14-8-17-18(25-10-24-17)9-16(14)19(21-22(11)12(2)23)13-3-5-15(20)6-4-13/h3-6,8-9,11H,7,10,20H2,1-2H3/t11-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 100 mg/mL (296.41 mM)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Talampanel (orally administration; 5 mg/kg; once a day; 2 weeks) reduces motoneuronal calcium in a mouse model of ALS, but its efficacy declines as the disease progresses.|References:|Paizs M, et al. Talampanel reduces the level of motoneuronal calcium in transgenic mutant SOD1 mice only if applied presymptomatically. Amyotroph Lateral Scler. 2011 Sep;12(5):340-4.Denes L, et al. Talampanel a non-competitive AMPA-antagonist attenuates caspase-3 dependent apoptosis in mouse brain after transient focal cerebral ischemia. Brain Res Bull. 2006 Jul 31;70(3):260-2. Epub 2006 Mar 31.Products are for research use only. Not for human use.|