Product Name :
GSK-LSD1 2HCl
Description:
GSK-LSD1 2HCl is a selective inhibitor of LSD1 with IC50 value of 16 nM . Lysine (K) -specific demethylase 1A (LSD1) is a flavin-dependent histone demethylase that demethylates mono- and di-methylated lysines and plays an important role in oocyte growth, embryogenesis and tissue-specific differentiation. LSD1 plays a role in acute myeloid leukemia (AML). GSK-LSD1 2HCl irreversibly inhibited LSD1 with IC50 value of 16 nM and is > 1000 fold selective over LSD2, MAO-A and MAO-B, which were related to FAD utilizing enzymes. In cancer cell lines, GSK-LSD1 2HCl changed gene expression with average EC50 value < 5 nM and inhibited cells growth with average EC50 value < 5 nM. GSK-LSD1 2HCl (10 ?M) inhibited human recombinant dopamine transporter, 5-HT1A and 5-HT transporter by 39%, 49% and 74%, respectively. And no activity against other 55 recombinant receptors (GPCR, transporters, ion channels). GSK-LSD1 2HCl can be used as a chemical probe and a part of the SGC epigenetics .
CAS:
1431368-48-7
Molecular Weight:
216.32
Formula:
C14H20N2
Chemical Name:
N-[(1R,2S)-2-phenylcyclopropyl]piperidin-4-amine
Smiles :
C1[C@H]([C@@H]1NC1CCNCC1)C1C=CC=CC=1
InChiKey:
BASFYRLYJAZPPL-UONOGXRCSA-N
InChi :
InChI=1S/C14H20N2/c1-2-4-11(5-3-1)13-10-14(13)16-12-6-8-15-9-7-12/h1-5,12-16H,6-10H2/t13-,14+/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
GSK-LSD1 2HCl is a selective inhibitor of LSD1 with IC50 value of 16 nM . Lysine (K) -specific demethylase 1A (LSD1) is a flavin-dependent histone demethylase that demethylates mono- and di-methylated lysines and plays an important role in oocyte growth, embryogenesis and tissue-specific differentiation. LSD1 plays a role in acute myeloid leukemia (AML). GSK-LSD1 2HCl irreversibly inhibited LSD1 with IC50 value of 16 nM and is > 1000 fold selective over LSD2, MAO-A and MAO-B, which were related to FAD utilizing enzymes.{{Pexidartinib} MedChemExpress|{Pexidartinib} c-Fms|{Pexidartinib} Biological Activity|{Pexidartinib} Formula|{Pexidartinib} manufacturer|{Pexidartinib} Epigenetics} In cancer cell lines, GSK-LSD1 2HCl changed gene expression with average EC50 value Product information|CAS Number: 1431368-48-7|Molecular Weight: 216.{{Amifostine} MedChemExpress|{Amifostine} Apoptosis|{Amifostine} Purity & Documentation|{Amifostine} References|{Amifostine} custom synthesis|{Amifostine} Epigenetic Reader Domain} 32|Formula: C14H20N2|Chemical Name: N-[(1R,2S)-2-phenylcyclopropyl]piperidin-4-amine|Smiles: C1[C@H]([C@@H]1NC1CCNCC1)C1C=CC=CC=1|InChiKey: BASFYRLYJAZPPL-UONOGXRCSA-N|InChi: InChI=1S/C14H20N2/c1-2-4-11(5-3-1)13-10-14(13)16-12-6-8-15-9-7-12/h1-5,12-16H,6-10H2/t13-,14+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:23074147 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|