Product Name :
(Z)-TG003
Description:
TG003 is a potent and ATP-competitive Cdc2-like kinase (Clk) inhibitor with IC50 of 20 nM, 200 nM, and 15 nM for Clk1, Clk2, and Clk4, respectively. No inhibitory effect on Clk3, SRPK1, SRPK2, or PKC.
CAS:
300801-52-9
Molecular Weight:
249.33
Formula:
C13H15NO2S
Chemical Name:
(1Z)-1-(3-ethyl-5-methoxy-1, 3-benzothiazol-2-ylidene)propan-2-one
Smiles :
CC(=O)/C=C1\SC2=CC=C(C=C2N\1CC)OC
InChiKey:
BGVLELSCIHASRV-QPEQYQDCSA-N
InChi :
InChI=1S/C13H15NO2S/c1-4-14-11-8-10(16-3)5-6-12(11)17-13(14)7-9(2)15/h5-8H,4H2,1-3H3/b13-7-
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.{{2,8-Dihydroxyadenine} site|{2,8-Dihydroxyadenine} Endogenous Metabolite|{2,8-Dihydroxyadenine} Protocol|{2,8-Dihydroxyadenine} Purity|{2,8-Dihydroxyadenine} supplier|{2,8-Dihydroxyadenine} Epigenetics}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
TG003 is a potent and ATP-competitive Cdc2-like kinase (Clk) inhibitor with IC50 of 20 nM, 200 nM, and 15 nM for Clk1, Clk2, and Clk4, respectively. No inhibitory effect on Clk3, SRPK1, SRPK2, or PKC.|Product information|CAS Number: 300801-52-9|Molecular Weight: 249.33|Formula: C13H15NO2S|Chemical Name: (1Z)-1-(3-ethyl-5-methoxy-1, 3-benzothiazol-2-ylidene)propan-2-one|Smiles: CC(=O)/C=C1\SC2=CC=C(C=C2N\1CC)OC|InChiKey: BGVLELSCIHASRV-QPEQYQDCSA-N|InChi: InChI=1S/C13H15NO2S/c1-4-14-11-8-10(16-3)5-6-12(11)17-13(14)7-9(2)15/h5-8H,4H2,1-3H3/b13-7-|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Solubility (25°C).{{Phenol Red sodium salt} medchemexpress|{Phenol Red sodium salt} {Fluorescent Dye}|{Phenol Red sodium salt} Biological Activity|{Phenol Red sodium salt} In Vitro|{Phenol Red sodium salt} custom synthesis|{Phenol Red sodium salt} Autophagy} 6 mg/mLwarmed(24.PMID:23659187 06 mM). Insoluble.|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|TG003 inhibits SF2/ASF-dependent splicing of human β-globin in vitro by suppression of Clk1/Sty-mediated phosphorylation. TG003 inhibits Clk1/Sty kinase activity in mammalian cells, while has no toxic effect on growth of HeLa and COS-7 cells at 10 μM concentration. TG003 blocks IL-1β RNA production by platelets by inhibiting splicing of IL-1β heteronuclear RNA. During 3T3-L1 adipocyte differentiation, TG003 also blocks alternative splicing of PKCβII and expression of PPARγ1 and PPARγ2.|In Vivo:|TG003 (10 μM) rescues the embryonic defects induced by excessive Clk activity in Xenopus.|Products are for research use only. Not for human use.|