, Kaneko T, Azuma T, Nagata H, et al: AICAR, an AMPK activator, has protective effects on alcohol-induced fatty liver in rats. Alcohol Clin Exp Res 2005, 29:240S45S. Shimano H, Horton JD, Shimomura I, Hammer RE, Brown MS, Goldstein JL: Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells. J Clin Invest 1997, 99:84654. Edwards PA, Tabor D, Kast HR, Venkateswaran A: Regulation of gene expression by SREBP and SCAP. Biochim Biophys Acta 2000, 1529:10313. Sekiya M, Yahagi N, Matsuzaka T, Takeuchi Y, Nakagawa Y, Takahashi H, Okazaki H, Iizuka Y, Ohashi K, Gotoda T, et al: SREBP-1-independent regulation of lipogenic gene expression in adipocytes. J Lipid Res 2007, 48:1581591. Magana MM, Osborne TF: Two tandem binding sites for sterol regulatory element binding proteins are needed for sterol regulation of fatty-acid synthase promoter. J Biol Chem 1996, 271:326892694. Porstmann T, Santos CR, Griffiths B, Cully M, Wu M, Leevers S, Griffiths JR, Chung YL, Schulze A: SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell development. Cell Metab 2008, 8:22436. Ericsson J, Jackson SM, Kim JB, Spiegelman BM, Edwards PA: Identification of glycerol-3-phosphate acyltransferase as an adipocyte determination and differentiation factor 1- and sterol regulatory element-binding protein-responsive gene. J Biol Chem 1997, 272:7298305. Hwahng SH, Ki SH, Bae EJ, Kim HE, Kim SG: Function of adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway in repression of liver X receptor-alpha-dependent lipogenic gene induction and hepatic steatosis by a novel class of dithiolethiones. Hepatology 2009, 49:1913925. Hancock CR, Han DH, Chen M, Terada S, Yasuda T, Wright DC, Holloszy JO: High-fat diets bring about insulin resistance regardless of an increase in muscle mitochondria.Inorganic pyrophosphatase Proc Natl Acad Sci USA 2008, 105:7815820.Dipyridamole Fillmore N, Jacobs DL, Mills DB, Winder WW, Hancock CR: Chronic AMP-activated protein kinase activation plus a high-fat eating plan have anHenriksen et al.PMID:35901518 Diabetology Metabolic Syndrome 2013, five:29 http://www.dmsjournal/content/5/1/Page 11 of40.41. 42. 43.44.45.46.47.48.49.50.51.52.53.54.55.56.57.58.59.additive effect on mitochondria in rat skeletal muscle. J Appl Physiol 2010, 109:51120. Garcia-Roves P, Huss JM, Han DH, Hancock CR, Iglesias-Gutierrez E, Chen M, Holloszy JO: Raising plasma fatty acid concentration induces enhanced biogenesis of mitochondria in skeletal muscle. Proc Natl Acad Sci USA 2007, 104:107090713. Srere PA: Controls of citrate synthase activity. Life Sci 1974, 15:1695710. Folch J, Lees M, Sloane Stanley GH: A basic strategy for the isolation and purification of total lipides from animal tissues. J Biol Chem 1957, 226:49709. Schlossman DM, Bell RM: Triacylglycerol synthesis in isolated fat cells. Proof that the sn-glycerol-3-phosphate and dihydroxyacetone phosphate acyltransferase activities are dual catalytic functions of a single microsomal enzyme. J Biol Chem 1976, 251:5738744. Watt MJ, Holmes AG, Steinberg GR, Mesa JL, Kemp BE, Febbraio MA: Lowered plasma FFA availability increases net triacylglycerol degradation, but not GPAT or HSL activity, in human skeletal muscle. Am J Physiol Endocrinol Metab 2004, 287:E12027. Hou X, Xu S, Maitland-Toolan KA, Sato K, Jiang B, Ido Y, Lan F, Walsh K, Wierzbicki M, Verbeuren TJ, et al: SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase. J Biol Ch.