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Evaluation of your Antitumor Activity of Dacomitinib in Models of Human Bladder CancerPetros D Grivas,1,4,5 Kathleen C Day,three,4,5 Andreas Karatsinides,three Alyssa Paul,3 Nazia Shakir,three Iya Owainati,three Monica Liebert,3 Lakshmi P Kunju,2 Dafydd Thomas,2 Maha Hussain,1,three,five and Mark L Day3,4,1Division of Hematology/Oncology, Division of Internal Medicine, 2Department of Pathology, 3Department of Urology, Translational Oncology Program, and 5University of Michigan Complete Cancer Center, University of Michigan, Ann Arbor, Michigan, United states of AmericaMembers of your human epidermal development element receptor (HER) family play a substantial role in bladder cancer progression and may underlie the development of chemotherapy resistance. Dacomitinib is an irreversible tyrosine kinase inhibitor with structural specificity for the c.