N, performed the experiments; Jie Feng, Megan Weitner, David Sullivan, and
N, performed the experiments; Jie Feng, Megan Weitner, David Sullivan, and Ying Zhang analyzed the data; and Megan Weitner, Jie Feng, Ying Zhang wrote the paper. Conflicts of Interest The authors declare no conflict of interest. References 1. 2. Centers for Illness Manage and Prevention. Lyme Illness. Obtainable on line: cdc.gov/lyme/ (accessed on five June 2015). Hinckley, A.F.; Connally, N.P.; Meek, J.I.; Johnson, B.J.; Kemperman, M.M.; Feldman, K.A.; White, J.L.; Mead, P.S. Lyme illness testing by large commercial laboratories within the Usa. Clin. Infect. Dis. 2014, 59, 676sirtuininhibitor81. Radolf, J.D.; Caimano, M.J.; Stevenson, B.; Hu, L.T. Of ticks, mice and guys: Understanding the dual-host lifestyle of lyme disease CD83, Human (HEK293, Fc) spirochaetes. Nat. Rev. Microbiol. 2012, 10, 87sirtuininhibitor9. Wormser, G.P.; Dattwyler, R.J.; Shapiro, E.D.; Halperin, J.J.; Steere, A.C.; Klempner, M.S.; Krause, P.J.; Bakken, J.S.; Strle, F.; Stanek, G.; et al. The clinical assessment, remedy, and prevention of lyme disease, human granulocytic anaplasmosis, and babesiosis: Clinical practice recommendations by the infectious ailments society of america. Clin. Infect. Dis. 2006, 43, 1089sirtuininhibitor134. Centers for Disease Control and Prevention. Post Remedy Lyme Disease. Offered on the web: cdc.gov/lyme/postLDS (accessed on five June 2015). Adrion, E.R.; Aucott, J.; Lemke, K.W.; Weiner, J.P. Wellness care expenses, utilization and patterns of care following lyme disease. PLoS 1 2015, 10, e0116767. Aucott, J.N.; Rebman, A.W.; Crowder, L.A.; Kortte, K.B. Post-treatment lyme disease syndrome symptomatology and also the influence on life functioning: Is there anything theresirtuininhibitor Qual. Life Res. 2013, 22, 75sirtuininhibitor4. Phillips, S.E.; Mattman, L.H.; Hulinska, D.; Moayad, H. A proposal for the reputable culture of Borrelia burgdorferi from individuals with chronic lyme illness, even from those previously aggressively treated. Infection 1998, 26, 364sirtuininhibitor67.3. four.5. six. 7.eight.Antibiotics 2015, 4 9. ten.11. 12. 13.14. 15. 16. 17. 18.19.20.21.22. 23.24.25.Barthold, S.W.; Hodzic, E.; Imai, D.M.; Feng, S.; Yang, X.; Luft, B.J. Ineffectiveness of tigecycline against persistent Borrelia burgdorferi. Antimicrob. Agents Chemother. 2010, 54, 643sirtuininhibitor51. Embers, M.E.; Barthold, S.W.; Borda, J.T.; Bowers, L.; Doyle, L.; Hodzic, E.; Jacobs, M.B.; Hasenkampf, N.R.; Martin, D.S.; Narasimhan, S.; et al. Persistence of Borrelia burgdorferi in Rhesus macaques following antibiotic remedy of disseminated infection. PLoS One 2012, 7, e29914. Hodzic, E.; Imai, D.; Feng, S.; Barthold, S.W. STUB1 Protein Storage & Stability Resurgence of persisting non-cultivable Borrelia burgdorferi following antibiotic therapy in mice. PLoS A single 2014, 9, e86907. Straubinger, R.K.; Summers, B.A.; Chang, Y.F.; Appel, M.J. Persistence of Borrelia burgdorferi in experimentally infected dogs right after antibiotic treatment. J. Clin. Microbiol. 1997, 35, 111sirtuininhibitor16. Marques, A.; Telford, S.R., 3rd; Turk, S.P.; Chung, E.; Williams, C.; Dardick, K.; Krause, P.J.; Brandeburg, C.; Crowder, C.D.; Carolan, H.E.; et al. Xenodiagnosis to detect Borrelia burgdorferi infection: A first-in-human study. Clin. Infect. Dis. 2014, 58, 937sirtuininhibitor45. Hodzic, E.; Feng, S.; Holden, K.; Freet, K.J.; Barthold, S.W. Persistence of Borrelia burgdorferi following antibiotic remedy in mice. Antimicrob. Agents Chemother. 2008, 52, 1728sirtuininhibitor736. Bayer, M.E.; Zhang, L.; Bayer, M.H. Borrelia burgdorferi DNA in the uri.