S tester (TBH 325 TD, Basel, Switzerland), which simultaneously determined the thickness and diameter. Typical and regular deviation of hardness, thickness and diameter have been presented (n=10). Study of water uptake and erosion: To be able to evaluate the water uptake and erosion of every tablet, the tablets have been individually ATGL list weighed prior to dissolution testing as original dry weight. Immediately after dissolution test, each and every tablet was blotted to get rid of excess water and immediately weighed on analytical VEGFR Molecular Weight balance as wet weight after which all of them have been dried at 60for 24 h and kept in desiccator for at the least 3 days and individually weighed as remaining dry weight. Water uptake and erosion wereMATERIALS AND METHODSHydrochlorothiazide (HCT, batch No I 1413891 was supplied by Government of Pharmaceutical Organization, Thailand). Propranolol HCl (PRO, lot no M080311, Pc Drug Co., Ltd., Bangkok, Thailand), Lutrol F127 (L) (lot no WPDF563B, BASF, Ludwigshafen, Germany) and shellac wax (S) (Ake Shellac Co., Ltd., Lumpang, Thailand) had been made use of as received. Ethylene glycol (lot no.1341646,January – FebruaryIndian Journal of Pharmaceutical Sciencesijpsonlineevaluated gravimetrically based on the following Eqns., water uptake=(wet weight emaining dry weight)/remaining dry weight)00….(Eqn. 1) and erosion=((original dry weight emaining dry weight)/original dry weight)00….(Eqn. 2) Determination of contact angle and surface free of charge power (SFE): Speak to angle could describe the wettability of any compound within the formulation. Moreover, it was utilized to calculate the SFE of these compounds. SFE may be utilized to describe numerous properties of compounds which include polarity or the miscibility of mixed component [21]. In this experiment, SFE was calculated employing Wu’s Eqn., expressed beneath.(1 + COS ) 1 = four( 1d 2 d ) 4( 1 p 2 p ) + p 1d + 2 d 1 + 2pThe cumulative drug release of PRO or HCT had been calculated and plotted against time. The dissolution of combined PRO and HCT matrix tablets have been studied together with the strategy as previously described. On the other hand, the level of drug release was determined using first derivative UVspectroscopy technique (FUV). Drug release amount was determined at 297 and 336 nm for PRO and HCT, respectively. The cumulative drug release of PRO and HCT had been calculated and plotted against time. The simultaneous determination of two drugs content material was measured with FUV along with the obtained spectra (D1) at 297 and 336 nm for PRO and HCT, respectively, was employed for this study. Selection of linearity of PRO and HCT was 1.5-7.five (r 2=0.9999) and 3.6-18.0 /ml (r 2=0.9996), respectively. Recovery of PRO and HCT was 106.59 and 97.11, respectively. Precision was determined as intraday and interday precision. The RSD of intraday precision was 2.46 and 1.88 for PRO and HCT, respectively. For interday precision, the RSD was two.23 and 1.57 for PRO and HCT, respectively. LOD of standard curve was discovered to be 0.ten and 0.49 /ml for PRO and HCT, respectively. LOQ was 0.31 and 1.48 /ml for PRO and HCT, respectively. Mechanisms of drug release were evaluated by fitting of cumulative drug release information with mathematical release models. The models applied in this experiment had been zero order, 1st order, Higuchi’s model, power law expression and Hixson-Crowell cube root equation. The experimental cumulative drug release information within the selection of 10-80 have been employed to evaluate the kinetic of drug release by least square fitting process. The data were fitted using the mathematical Eqns by nonli.