gulant and vacuum-separated gel blood collection vessels, respectively, and stored at -80 C for subsequent testing. FPG, TC, HDL-C, LDL-C, HCY, folic acid, vitamin D2, and vitamin D3 concentrations had been measured with an Advia Clinical Chemistry Technique (Siemens Healthcare, Erlangen, Germany).Serum indicatorsHyperlipidemia Tumor History of fracture Nephrosis problems Gastrointestinal issues FBG (mmol/L) HbA1C (mg/dl) TC (mmol/L)two.Statistical analysisHDL-C (mmol/L) LDL-C (mmol/L) HCY (mol/L) Folic acid (mmol/L) Vitamin D2 (mmol/L) Vitamin D3 (mmol/L)SPSS L-type calcium channel Agonist Biological Activity version 23 (IBM, USA) was employed to analyze all datasets. Discrete information are provided as numbers or percentages and continuous data having a typical distribution because the imply SD. To analyze possible risk components affecting dementia, uni- and multivariate logistic regression was employed. Information are offered with 95 self-confidence intervals. The predictive potential of indicators for dementia was evaluated by receiver operating characteristic (ROC) analysis. The cutoff values for indicators have been determined by ROC analyses (Youden Index). Variables with statistical significance within the univariate analysis had been combined in distinct techniques, to judge the diagnostic effect (ROC) of distinct combinations. Lastly, the optimal mixture (the largest area below the ROC curve) was advised in accordance with the fitting efficiency of distinct mixture models. A statistically substantial getting was deemed to become a two-sided p-value .05.Abbreviations: FBG, Caspase Activator Species fasting blood glucose; HbA1C, hemoglobin A1C; HCY, homocysteine; HDL-C, high-density lipoprotein cholesterol; LDL-C, lowdensity lipoprotein cholesterol; TC, total cholesterol.hypertension, and cardiac problems had been the top rated 3 comorbidities, accounting for 74.2 , 59.five , and 38.9 , respectively (Table 1).three.two Univariate evaluation from the general qualities of dementia three RESULTSPatients with dementia were substantially older than patients devoid of dementia, but there was no difference in gender. Respiratory problems (OR: 1.411, p .001), fractures (OR: 1.202, p .001), cardiac issues (OR: 1.123, p .001), hypertension (OR: 1.120, p .001), A total of 4722 elderly individuals had been integrated, with an typical age of 73.0 15.five years, and 52.5 have been males. Many of the patients were in the Division of Neurology (77.eight ). There were 565 patients with dementia, with an incidence rate of 12 . Cerebrovascular issues, and cerebrovascular disorders (OR: 1.080, p .001) have been associated using a larger risk for the incidence of dementia. Nonetheless, diabetes did not raise the threat of establishing dementia. In the point of view on the number of comorbidities, OR improved with the quantity of3.1 Patient traits and baseline information4 ofGONG ET AL .TA B L EUnivariate evaluation of gender, age, and comorbidities for dementiaDementia (n = 565) Nondementia (n = 4157) 2178 (52.four) 1979 (47.six) 71.two 15.4 3238 (77.9) 919 (22.1) 1722 (41.four) 2435 (58.6) 3853 (92.7) 304 (7.three) 4094 (98.five) 63 (1.five) 4081 (98.2) 76 (1.eight) 1120 (26.9) 3037 (73.1) 3108 (74.eight) 1049 (25.two) 4147 (99.8) ten (0.two) 2678 (64.four) 1479 (35.6) 3968 (95.five) 189 (4.five) 376 (9.0) 194 (four.7) 43 (1.0) 393 (9.5) 124 (three.0) 3027 (72.eight)OR (95 CI) 1.0 0.965 (0.809.151) 1.122 (1.109.135) 1.0 1.411 (1.285.549) 1.0 1.120 (1.053.192) 1.0 0.767 (0.672.875) 1.0 1.202 (1.087.329) 1.0 0.958 (0.847.082) 1.0 1.080 (1.046.116) 1.0 1.0 (0.976.026) 1.0 0.258 (0.001999.9) 1.0 1.123 (1.102.143) 1.0 0.962 (0.919.007) 1.0 7.75 (two.167.76) 8.