Es for the prevention of stroke in nonvalvular atrial fibrillation and venous thromboembolism [1]. While it was related with a greater reduction within the price of stroke as well as a decrease rate of bleeding compared to warfarin inside the ARISTOTLE trial, it was connected with an elevated threat of key bleeding (such as hemopericardium) defined working with the International Society on Thrombosis and Hemostasis (ISTH) criteria; at an incident price of two.13 per year [2,3]. Even so, the percentage of hemopericardium in comparison to other bleeding sites was not integrated in the trial outcomes [2,3]. Hemopericardium would be the accumulation of blood in the pericardial space [4]. This could bring about lifethreatening hemodynamic compromise, cardiac tamponade depending on the rate and volume of blood accumulation [4]. Reported CYP1 Activator custom synthesis causes are infection (in particular tuberculosis), metastasis of malignant cells towards the pericardium, thoracic aortic dissection, cardiac surgery, acute myocardial infarction, trauma, pericarditis, and bleeding diathesis [3]. We present a case of hemopericardium inside a patient taking apixaban for paroxysmal atrial fibrillation.Assessment started 01/26/2021 Overview ended 02/22/2021 Published 02/22/2021 Copyright 2021 Olagunju et al. This is an open access write-up distributed under the terms from the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, supplied the original author and supply are credited.Case PresentationAn 80-year-old male with a past medical history of paroxysmal atrial fibrillation, heart failure with preserved ejection fraction, chronic obstructive CA Ⅱ Inhibitor Storage & Stability pulmonary disease, tobacco dependence, benign crucial hypertension, and stage three chronic kidney disease presented towards the emergency department (ED) with shortness of breath, orthopnea, growing reduce extremity edema, and cough of two weeks’ duration. The cough was productive with white sputum and worse in the supine position. He denied hemoptysis, chest discomfort, fever, chills, evening sweat, fat reduction, nausea, and vomiting. His paroxysmal atrial fibrillation was diagnosed two weeks prior when he was admitted and treated for COPD exacerbation and cellulitis with the ideal shin. He converted to sinus rhythm soon after receiving 20mg IV diltiazem. Depending on his CHA2DS2VASc score of 4, he was discharged residence with 5mg twice each day (BID) of apixaban and metoprolol succinate 12.5mg BID for price handle; he was also began on amiodarone 200mg day-to-day outpatient. A transthoracic echocardiogram before discharge revealed a typical ejection fraction of 62 with grade 2 diastolic dysfunction (Figure 1).How to cite this short article Olagunju A, Khatib M, Palermo-Alvarado F (February 22, 2021) A Doable Drug-Drug Interaction Between Eliquis and Amiodarone Resulting in Hemopericardium. Cureus 13(two): e13486. DOI ten.7759/cureus.FIGURE 1: Parasternal long-axis view of the patient’s baseline echocardiogram did not show pericardial effusion.On presentation towards the ED, he was tachypneic using a respiratory price of 32 breaths per minute and oxygen saturation of 91 on space air, his heart price was 77 beats per minute and blood pressure was 114/78mmHg. Physical examination was remarkable for jugular venous distention, distant heart sounds, and 3+ bilateral decrease extremity edema as much as his shins. Abnormal laboratory findings on admission have been hemoglobin of ten.8g/dL (his baseline is 12g/dL), creatinine of 1.67mg/dL (his baseline is 1.42mg/dL), glomerular filtration price.