Product: Bay-K-8644 ((S)-(-)-)
PKC iota Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the C-terminus region of human PKC iota. The exact sequence is proprietary.
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| Localization |
Cytoplasm; Membrane; Endosome; Nucleus
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| Isotype |
IgG
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
PRKCI
|
| Purity |
Immunogen affinity purified
|
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Applications/Dilutions
| Dilutions |
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| Application Notes |
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
|
| Theoretical MW |
68 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
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| Preservative |
0.01% Thimerosal
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| Concentration |
0.69 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for PKC iota Antibody
- aPKC-lambda/iota
- Atypical protein kinase C-lambda/iota
- DXS1179E
- EC 2.7.11
- EC 2.7.11.13
- MGC26534
- nPKC-iota
- PKCI
- PRKC-lambda/iota
- protein kinase C iota type
- protein kinase C, iota
Background
This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq]