Product: Tenovin-2

Cytohesin 2 Antibody Summary

Immunogen
Peptide with sequence EDGVYEPPDLTP-C corresponding to N-Terminus according to NP_059431.1.
Epitope
EDGVYEPPDLTP
Specificity
This antibody is expected to recognise both reported isoforms (NP_004219.2; NP_059431.1).
Clonality
Polyclonal
Host
Goat
Gene
CYTH2
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 0.5 – 1.5 ug/ml
  • Peptide ELISA Detection limit 1:32000
Application Notes
WB: Approx. 48 kDa band observed in human brain (cerebellum) and rat brain lysates (calculated MW of 46.5 kDa band according to NP_004219.2 and NP_059431.1).
Positive Control
Cytohesin 2 Lysate (NBL1-14857)
Publications
Read Publication using NB100-77340.

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Mouse, Canine.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Cytohesin 2 Antibody

  • ARF exchange factor
  • ARF nucleotide-binding site opener
  • ARNOPH, SEC7 and coiled-coil domain-containing protein 2
  • CTS18.1
  • cytohesin 2
  • pleckstrin homology, Sec7 and coiled-coil domains 2 (cytohesin-2)
  • Protein ARNO
  • PSCD2LCTS18
  • PSCD2pleckstrin homology, Sec7 and coiled-coil domains 2
  • Sec7 and coiled/coil domains 2 (cytohesin-2)

Background

Pleckstrin homology, Sec7 and coiled/coil domains 2 (PSCD2) is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. PSCD2 exhibits GEP activity in vitro with ARF1, ARF3, and ARF6. PSCD2 protein is 83% homologous to PSCD1. Two transcript variants encoding different isoforms have been found for this gene.

PMID: 871093

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