Product: GSK137647A

CD34 Antibody (581) [FITC] Summary

Immunogen
CD34 (Mucosialin) (NM_001025109.1).
Marker
Hematopoietic Stem Cell Marker
Specificity
The mouse monoclonal antibody 581 reacts with CD34 (Mucosialin), a 110-115 kDa monomeric transmembrane phosphoglycoprotein expressed on hematopoietic progenitors cells and on the most pluripotential stem cells; it is gradually lost on progenitor cells. The antibody recognizes the class III CD34 epitope resistant to neuraminidase, chymopapain and glycoprotease.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
CD34
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry 4ul reagent / 100ul of whole blood

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS and 0.2% (w/v) high grade BSA (protease free)
Preservative
15mM Sodium Azide
Purity
Protein A purified

Alternate Names for CD34 Antibody (581) [FITC]

  • CD34 antigenhematopoietic progenitor cell antigen CD34
  • CD34 molecule
  • CD34
  • HPCA1

Background

CD34 is a highly glycosylated monomeric 111-115 kDa surface protein, which ispresent on many stem cell populations. It is a well established stem cell marker,though its expression on human hematopoietic stem cells is reversible. CD34probably serves as a surface receptor that undergoes receptor-mediatedendocytosis and regulates adhesion, differentiation and proliferation ofhematopoietic stem cells and other progenitors. CD34 expression is likely torepresent a specific state of hematopoietic development that may have alteredadhering properties with expanding and differentiating capabilities in both in vitroand in vivo conditions.

PMID: 23619397

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