Product: Resminostat (hydrochloride)
5-Lipoxygenase Antibody Summary
| Immunogen |
Peptide with sequence C-ERNKKKQLPYYYLSPD corresponding to C-Terminus according to NP_000689.1.
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| Clonality |
Polyclonal
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| Host |
Goat
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| Gene |
ALOX5
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
WB: Approx. 85 kDa band observed in human bone marrow and rat stomach lysates (calculated MW of 77.7.0 kDa band according to rat NP_036954).
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
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| Theoretical MW |
78 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
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| Positive Control |
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| Publications |
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Reactivity Notes
Predicted cross-reactivity based on sequence identity: Mouse, Canine.
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
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| Buffer |
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
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| Preservative |
0.02% Sodium Azide
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| Concentration |
0.5 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for 5-Lipoxygenase Antibody
- 5Lipoxygenase
- 5-Lipoxygenase
- 5-LO
- 5-LOX
- 5LPG
- ALOX5
- arachidonate 5-lipoxygenase
- arachidonic 5-lipoxygenase alpha-10 isoform
- arachidonic 5-lipoxygenase delta-10-13 isoform
- arachidonic 5-lipoxygenase delta-13 isoform
- arachidonic 5-lipoxygenase delta-p10 isoform
- arachidonic acid 5-lipoxygenase
- EC 1.13.11
- EC 1.13.11.34
- leukotriene A4 synthase
- LOG5
- LOX5A
- MGC163204
Background
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined.