Product Name :
L-689560
Description:
L-689560 is a potent N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. L-689560 is widely used as a radiolabeled ligand in binding studies and used for study the roles of NMDA receptors in normal neurological processes as well as in diseases.
CAS:
139051-78-8
Molecular Weight:
380.23
Formula:
C17H15Cl2N3O3
Chemical Name:
(2S,4S)-5,7-dichloro-4-[(phenylcarbamoyl)amino]-1,2,3,4-tetrahydroquinoline-2-carboxylic acid
Smiles :
OC(=O)[C@@H]1C[C@H](NC(=O)NC2C=CC=CC=2)C2C(=CC(Cl)=CC=2Cl)N1
InChiKey:
UCKHICKHGAOGAP-KBPBESRZSA-N
InChi :
InChI=1S/C17H15Cl2N3O3/c18-9-6-11(19)15-12(7-9)21-14(16(23)24)8-13(15)22-17(25)20-10-4-2-1-3-5-10/h1-7,13-14,21H,8H2,(H,23,24)(H2,20,22,25)/t13-,14-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
L-689560 is a potent N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. L-689560 is widely used as a radiolabeled ligand in binding studies and used for study the roles of NMDA receptors in normal neurological processes as well as in diseases.|Product information|CAS Number: 139051-78-8|Molecular Weight: 380.23|Formula: C17H15Cl2N3O3|Chemical Name: (2S,4S)-5,7-dichloro-4-[(phenylcarbamoyl)amino]-1,2,3,4-tetrahydroquinoline-2-carboxylic acid|Smiles: OC(=O)[C@@H]1C[C@H](NC(=O)NC2C=CC=CC=2)C2C(=CC(Cl)=CC=2Cl)N1|InChiKey: UCKHICKHGAOGAP-KBPBESRZSA-N|InChi: InChI=1S/C17H15Cl2N3O3/c18-9-6-11(19)15-12(7-9)21-14(16(23)24)8-13(15)22-17(25)20-10-4-2-1-3-5-10/h1-7,13-14,21H,8H2,(H,23,24)(H2,20,22,25)/t13-,14-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Metformin medchemexpress |Shelf Life: ≥12 months if stored properly.Estrone Data Sheet |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:34028072 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|L-689560 is a 2-carboxytetrahydroquinoline antagonist.|In Vivo:|L-689560 (1 mg/kg, ip) significantly reduces the neuroprotective effect of glycine after glycine receptors and the channel activity of NMDA receptors (NMDARs) are suppressed. L-689560 blocks glycine-induced increase of Akt phosphorylation in the MCAO model|Products are for research use only. Not for human use.|