Product Name :
Rabbit anti-ZFP36L2 Polyclonal Antibody(Center)
Synonym :
Zinc finger protein 36; C3H1 type-like 2; ZFP36-like 2; Butyrate response factor 2; EGF-response factor 2; ERF-2; Protein TIS11D; ZFP36L2; BRF2; ERF2; RNF162C; TIS11D
Host :
Rabbit
Species Reactivity:
Human, Mouse
Specificity :
This ZFP36L2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 166-193 amino acids from the Central region of human ZFP36L2.
Predicted Reactivity:
Rat, Xenopus
Applications :
WB~~1:1000
Immunogen:
Concentration :
Purification :
Clonality:
Polyclonal Antibody
Storage Temp.:
Maintain refrigerated at 2-8 ° C for up to 2 weeksFor long term storage store at -20 ° C in small aliquots to prevent free that cycles
Research areas :
Cell Biology;Others
Background :
mRNA-binding protein that plays a key role in self- renewal of erythroid cells in response to glucocorticoids. Specifically binds to the AU-rich element (ARE) in the 3′-UTR of target mRNAs, promoting their deadenylation and degradation (PubMed:14981510). Specifically expressed in burst-forming unit- erythroid (BFU-E) progenitors in response to glucocorticoids and acts as a negative regulator of erythroid cell differentiation: promotes self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. Down-regulated during erythroid differentiation from the BFU-E stage, stabilizing mRNAs required for terminal differentiation (By similarity).
UniProt :
P47974
Additional information:
Product Details FAQ Citations(0) Video Pictures Documents |Overview |Synonym Zinc finger protein 36; C3H1 type-like 2; ZFP36-like 2; Butyrate response factor 2; EGF-response factor 2; ERF-2; Protein TIS11D; ZFP36L2; BRF2; ERF2; RNF162C; TIS11D |Host Rabbit |Specificity This ZFP36L2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 166-193 amino acids from the Central region of human ZFP36L2. |Species Reactivity Human, Mouse |Predicted Reactivity Rat, Xenopus |Applications WB~~1:1000 |Properties |Clonality Polyclonal Antibody |Isotype Rabbit Ig |Storage Temp. Maintain refrigerated at 2-8 ° C for up to 2 weeksFor long term storage store at -20 ° C in small aliquots to prevent free that cycles |Storage Buffer Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |Research areas Cell Biology;Others |Target |Background mRNA-binding protein that plays a key role in self- renewal of erythroid cells in response to glucocorticoids. Specifically binds to the AU-rich element (ARE) in the 3′-UTR of target mRNAs, promoting their deadenylation and degradation (PubMed:14981510). Specifically expressed in burst-forming unit- erythroid (BFU-E) progenitors in response to glucocorticoids and acts as a negative regulator of erythroid cell differentiation: promotes self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. Down-regulated during erythroid differentiation from the BFU-E stage, stabilizing mRNAs required for terminal differentiation (By similarity). |Cellular localization Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. |UniProt P47974 |References |References Morgan, B.R., et al. Protein Sci. 19(6):1222-1234(2010)Jackson, R.S. II, et al. Cell Cycle 5(24):2889-2893(2006)Hudson, B.P., et al. Nat. Struct. Mol. Biol. 11(3):257-264(2004)Blackshear, P.J., et al. Prog. Nucleic Acid Res. Mol. Biol. 75, 43-68 (2003) :Ino, T., et al. Oncogene 11(12):2705-2710(1995) |Tips:This product is for research use only. Not for use in diagnostic prodcedures.
Rabbit anti-ZFP36L2 Polyclonal Antibody(Center)
Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.Related websites: https://www.medchemexpress.com/antibodies.html
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