Product Name :
2-(2, 6-Dioxopiperidin-3-yl)phthalimidine
Description:
2-(2,6-Dioxopiperidin-3-yl)phthalimidine (EM-12), a teratogenic Thalidomide analogue, is more active than Thalidomide and is much more stable for hydrolysis. 2-(2,6-Dioxopiperidin-3-yl)phthalimidine enhances 1,2-dimethylhydrazine-induction of rat colon adenocarcinomas.
CAS:
26581-81-7
Molecular Weight:
244.25
Formula:
C13H12N2O3
Chemical Name:
3-(1-oxo-2, 3-dihydro-1H-isoindol-2-yl)piperidine-2, 6-dione
Smiles :
O=C1CCC(C(=O)N1)N1CC2=CC=CC=C2C1=O
InChiKey:
WENKGSGGXGQHSH-UHFFFAOYSA-N
InChi :
InChI=1S/C13H12N2O3/c16-11-6-5-10(12(17)14-11)15-7-8-3-1-2-4-9(8)13(15)18/h1-4,10H,5-7H2,(H,14,16,17)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
2-(2,6-Dioxopiperidin-3-yl)phthalimidine (EM-12), a teratogenic Thalidomide analogue, is more active than Thalidomide and is much more stable for hydrolysis. 2-(2,6-Dioxopiperidin-3-yl)phthalimidine enhances 1,2-dimethylhydrazine-induction of rat colon adenocarcinomas.|Product information|CAS Number: 26581-81-7|Molecular Weight: 244.25|Formula: C13H12N2O3|Chemical Name: 3-(1-oxo-2, 3-dihydro-1H-isoindol-2-yl)piperidine-2, 6-dione|Smiles: O=C1CCC(C(=O)N1)N1CC2=CC=CC=C2C1=O|InChiKey: WENKGSGGXGQHSH-UHFFFAOYSA-N|InChi: InChI=1S/C13H12N2O3/c16-11-6-5-10(12(17)14-11)15-7-8-3-1-2-4-9(8)13(15)18/h1-4,10H,5-7H2,(H,14,16,17)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Doxycycline Epigenetics |Shelf Life: ≥12 months if stored properly.Acarbose Data Sheet |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:33016683 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Young male Sprague-Dawley rats in 3 groups are fed a basal diet supplemented with 0.10 wt. % each of thalidomide and its imide-analog of much higher teratogenicity, 2-(2,6-Dioxopiperidin-3-yl)phthalimidine. Following an induction period of 17 days on the diets, all animals are injected subcutaneously with 1,2-dimethylhydrazine at 20 mg/kg for a total of 20 weekly doses and killed on week 18 after the 20th injection. 2-(2,6-Dioxopiperidin-3-yl)phthalimidine-fed group elicits statistically significant increases both in the total and ascending colon-based adenocarcinomas as compared with the control findings, in keeping with its greater teratogenicity and embryotoxicity.|Products are for research use only. Not for human use.|