Product Name :
Diloxanide
Description:
Diloxanide is an anti-protozoal agent and can be used for the research of asymptomatic-intestinal amebiasis caused by Entamoeba histolytica or some other protozoal infections. Diloxanide is an active luminal amebicide and hydrolyzed in the gastrointestinal tract from its prodrug Diloxanide furoate (HY-B1147).
CAS:
579-38-4
Molecular Weight:
234.08
Formula:
C9H9Cl2NO2
Chemical Name:
2,2-dichloro-N-(4-hydroxyphenyl)-N-methylacetamide
Smiles :
CN(C(=O)C(Cl)Cl)C1C=CC(O)=CC=1
InChiKey:
GZZZSOOGQLOEOB-UHFFFAOYSA-N
InChi :
InChI=1S/C9H9Cl2NO2/c1-12(9(14)8(10)11)6-2-4-7(13)5-3-6/h2-5,8,13H,1H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Diloxanide is an anti-protozoal agent and can be used for the research of asymptomatic-intestinal amebiasis caused by Entamoeba histolytica or some other protozoal infections. Diloxanide is an active luminal amebicide and hydrolyzed in the gastrointestinal tract from its prodrug Diloxanide furoate (HY-B1147).|Product information|CAS Number: 579-38-4|Molecular Weight: 234.08|Formula: C9H9Cl2NO2|Chemical Name: 2,2-dichloro-N-(4-hydroxyphenyl)-N-methylacetamide|Smiles: CN(C(=O)C(Cl)Cl)C1C=CC(O)=CC=1|InChiKey: GZZZSOOGQLOEOB-UHFFFAOYSA-N|InChi: InChI=1S/C9H9Cl2NO2/c1-12(9(14)8(10)11)6-2-4-7(13)5-3-6/h2-5,8,13H,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 33.{{Iberdomide} MedChemExpress|{Iberdomide} Apoptosis|{Iberdomide} Protocol|{Iberdomide} In stock|{Iberdomide} manufacturer|{Iberdomide} Epigenetics} 33 mg/mL (142.{{Phenytoin} web|{Phenytoin} Membrane Transporter/Ion Channel|{Phenytoin} Protocol|{Phenytoin} Purity|{Phenytoin} custom synthesis|{Phenytoin} Autophagy} 39 mM; Need ultrasonic).PMID:33144356 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Diloxanide is hydrolyzed in the gastrointestinal tract from its prodrug Diloxanide furoate. Diloxanide furoate (oral administraion; 75-200 mg/kg; 3 days; once daily) is effective at different dose of dayin weanling rats. At 200 mg/kg, 100% of the treated rats are cured and no amoebic lesions are observed in the caecum. Besides, 85%,77%, and 44.4% of the treated rats are cured at the dose 150 mg/kg, 100 mg/kg, and 75 mg/kg, respectively. The ED50 value is 77.9 mg/kg for this agent in rats.|Products are for research use only. Not for human use.|